"Rational agents should never be made worse off by more information—well, almost never. So if I can no longer contemplate the big picture without life seeming like a bad thing—the fewer needs you have, the fewer ways in which you can be hurt; if you don't exist, you can't be hurt—then maybe I could just—not contemplate it? If my will to live is something that can be destroyed by the truth, then maybe P. C. Hodgell was wrong? This needn't entail self-delusion: distraction is quite sufficient. There are plenty of things to do that won't remind me of the vastness of suffering in the multiverse.
"Daily life, exercise, practical programming skills, finding a job—pure math and compsci if I need something intellectual. But no philosophy, history, current events, futurism, social science, biology, or game theory. Not much fiction, because stories are about people's pain. I just don't want to know anymore."