Physical pain is the worst thing in the world, and the work of effective altruists will not be done until the last nociceptor falls silent and not a single moment of suffering remains to be computed across our entire future light cone.

But the emotional pain of discovering that your cherished belief is false, that everything you've ever cared about is not only utterly unattainable, but may in fact not even be coherent?—yeah, I'm pretty sadomasochistic about that. That's rationality; that's what it feels like to be alive.